Publications
Original papers and Reviews
2024
- Yusuke Sakamoto, Shota Fujii, Shin Takano, Jokichi Fukushima, Mitsuru Ando, Noriyuki Kodera, Tomoki Nishimura*
Manipulation of Macrophage Uptake by Controlling the Aspect Ratio of Graft Copolymer Micelles
Nano Letters, 2024, In press https://doi.org/10.1021/acs.nanolett.4c01054
UMass Amherst 藤井先生、University of Sydney 高野博士、京都大学医生物学研究所 安藤先生、
金沢大学ナノ生命科学研究所 古寺先生との共同研究の成果です。
- Daisuke Ogawa, Tomoki Nishimura, Yuta Nishina, Koki Sano*
A magnetically responsive photonic crystal of graphene oxide nanosheets
Nanoscale, 2024, 16, 7908 https://doi.org/10.1039/D3NR06114K
信州大学 佐野先生との共同研究の成果です。放射光SAXSによる構造解析をお手伝いさせていただきました。
- Naoki Ozawa, Tomoki Nishimura*
Macromolecular architectural effects on solution self-assembly of amphiphilic AB-type block copolymers
Polymer Chemistry, 2024, 15, 349 https://doi.org/10.1039/D3PY01324C
両親媒性ブロックコポリマーの1次構造と自己組織化挙動に関する総説論文です。
2023
- Riku Kawasaki*, Ayano Oshige, Keita Yamana, Hidetoshi Hirano, Kotaro Nishimura, Yamato Miura, Ryuji Yorioka, Yu Sanada, Kaori Bando, Anri Tabata, Kazuma Yasuhara, Yusuke Miyazaki, Wataru Shinoda, Tomoki Nishimura, Hideki Azuma, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka, Minoru Suzuki, Takeshi Nagasaki, Atsushi Ikeda*
HER-2-targeted Boron Neutron Capture Therapy with Carborane-integrated Immunoliposomes Prepared via an Exchanging Reaction
Chemistry A European Journal, 2023, 29, 72, e202302486 http://dx.doi.org/10.1002/chem.202302486
広島大学 池田先生、河崎先生との共同研究の成果です。分子集合体の構造解析をお手伝いさせていただきました。
- Naoki Ozawa, Ji Ha Lee, Isamu Akiba, Tomoki Nishimura*
Exploring the effects of glyco-copolymer architectures on the solution self-assembly of amphiphilic thermoresponsive linear, star, and cyclic polymers
Polymer Chemistry, 2023, 14, 3834 https://doi.org/10.1039/D3PY00729D
広島大学 Ji Ha Lee先生、北九州市立大学 秋葉 勇先生との共同研究の成果です。
- Shoma Kondo, Tomoki Nishimura, Yuta Nishina, Koki Sano*
Countercation Engineering of Graphene-Oxide Nanosheets for Imparting a Thermoresponsive Ability
ACS Applied Materials & Interfaces, 2023, 15, 31, 37837 https://pubs.acs.org/doi/10.1021/acsami.3c07820
信州大学 佐野先生との共同研究の成果です。放射光SAXSによる構造解析をお手伝いさせていただきました。
- Naoki Ozawa, Shunji Kosaka, Shota Fujii, Tomoki Nishimura*
Bilayer-domain formation of thermoresponsive amphiphilic block copolymers in hybrid liposomes for synthetic molecular channels
Polymer Chemistry, 2023, 14, 2198 https://pubs.rsc.org/en/content/articlelanding/2023/py/d3py00223c
UMass Amherst 藤井先生との共同研究の成果です。
- Riku Kawasaki*, Shogo Kawamura, Tomoki Kodama, Keita Yamana, Akira Maeda, Dilimulati Yimiti, Shigeru Miyaki, Shodai Hino, Naoki Ozawa, Tomoki Nishimura, Seiji Kawamoto, Atsushi Ikeda*
Development of a Water-Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response using a Mechanochemical Strategy
Macromolecular Bioscience, 2023,23, 4, 2200462 https://doi.org/10.1002/mabi.202200462
広島大学 池田先生、河崎先生との共同研究の成果です。ポリマーの構造解析をお手伝いさせていただきました。
- Sota Umezane, Satoshi Fukutomi, Toshikazu Ono*, Yoshio Hisaeda, Tomoki Nishimura, Riku Kawasaki, Atsushi Ikeda*
Fluorescence sensor using porous host molecules deposited on filter paper with vapochromic and mechanochromic properties
New Journal of Chemistry, 2023, 47, 4166 https://doi.org/10.1039/D2NJ04929E
広島大学 池田先生、河崎先生との共同研究の成果です。放射光WAXSによる構造解析をお手伝いさせていただきました。
2022
- Yusuke Sakamoto, Tomoki Nishimura*
Recent advances in the self-assembly of sparsely grafted amphiphilic copolymers in aqueous solution
Polymer Chemistry, 2022, 13, 6343 https://doi.org/10.1039/D2PY01018F
両親媒性グラフトポリマーの水溶液中での自己組織化挙動に関する総説論文です。
- Yota Okuno, Tomoki Nishimura, Yoshihiro Sasaki, Kazunari Akiyoshi*
Glycopeptoid Nanospheres: Glycosylation-Induced Coacervation of Poly(sarcosine)
Nanoscale Advances, 2022, 4, 3707 https://doi.org/10.1039/D2NA00218C
関西大 奥野先生、京大 秋吉先生のグループとの共同研究の成果です。
- Seok Gyu Kang, Ka Young Kim, Yumi Cho, Dong Yeun Jeong, Ji Ha Lee, Tomoki Nishimura, Shim Sung Lee, Sang Kyu Kwak*, Youngmin You*, Jong Hwa Jung*
Circularly Polarized Luminescence Active Supramolecular Nanotubes Based on Pt(II) Complexes that Undergo Dynamic Morphological Transformation and Helicity Inversion
Angewandte Chemie International Edition, 2022, 61, 38, e202207310 https://doi.org/10.1002/anie.202207310
Gyeongsang National University Jong Hwa Jung先生のグループとの共同研究の成果です。
放射光SWAXSによる構造解析をお手伝いさせていただきました。
- Fumi Suehiro, Shota Fujii, Tomoki Nishimura*
Bioorthogonal micellar nanoreactors for prodrug cancer therapy using an inverse-electron-demand Diels–Alder reaction
Chemical Communications, 2022, 58, 7026, https://doi.org/10.1039/D2CC02121H
北九州市立大学 藤井先生との共同研究の成果です。
- Tomoki Nishimura*, Yusuke Hatatani, Mitsuru Ando, Yoshihiro Sasaki, Kazunari Akiyoshi*
Single-component nanodiscs via the thermal folding of amphiphilic graft copolymers with the adjusted flexibility of the main chain
Chemical Science, 2022, 13, 5243, https://doi.org/10.1039/d2sc01674e 
- Yusuke Sakamoto§, Fumi Suehiro§, Isamu Akiba, Tomoki Nishimura*
Supramolecular Shear-Thinning Glycopeptide Hydrogels for Injectable Enzyme Prodrug Therapy Applications
Langmuir, 2022, 38, 18, 5883, https://doi.org/10.1021/acs.langmuir.2c00504
§: These authors contributed equally to this work.
北九州市立大学 秋葉先生との共同研究の成果です。
- Riku Kawasaki*, Kosuke Kondo, Risako Miura*, Keita Yamana, Hinata Isozaki, Risako Shimada, Shogo Kawamura, Hidetoshi Hirano, Tomoki Nishimura, Naoki Tarutani, Kiyofumi Katagiri, Alexandra Stubelius, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, Atsushi Ikeda*
Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy
International Journal of Molecular Sciences, 2022, 23, 9, 4686 https://doi.org/10.3390/ijms23094686
広島大学 河崎先生、池田先生との共同研究の成果です。放射光WAXSによる構造解析をお手伝いさせていただきました。
- Yoshiro Tahara, Riko Mizuno, Tomoki Nishimura, Sada-atsu Mukai, Rie Wakabayashi, Noriho Kamiya, Kazunari Akiyoshi, Masahiro Goto*
A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect
Biomaterials, 2022, 282, 121385, https://doi.org/10.1016/j.biomaterials.2022.121385
同志社大学 田原先生、九州大学 後藤先生との共同研究の成果です。放射光SAXSによる構造解析をお手伝いさせていただきました。
2021
- Riku Omokawa, Riku Kawasaki, Kouta Sugikawa, Tomoki Nishimura, Toshimi Nakaya, Atsushi Ikeda*
Preparation of Aqueous Solutions with Information on Solids (ASIS) of a Mechanochromic Luminescent Tetraphenylethylene Derivative by Complexation with Polysaccharides
ACS Applied Polymer Materials, 2021, 3, 8, 3708, https://doi.org/10.1021/acsapm.1c00646
広島大学池田先生との共同研究の成果です。放射光WAXSによる構造解析をお手伝いさせていただきました。
- Tomoki Nishimura*, Shota Fujii, Kazuo Sakurai, Yoshihiro Sasaki, Kazunari Akiyoshi*
Manipulating the Morphology of Amphiphilic Graft-Copolymer Assemblies by Adjusting the Flexibility of the Main Chain
Macromolecules, 2021, 54, 14, 7003, https://doi.org/10.1021/acs.macromol.1c01030
- Yota Okuno, Tomoki Nishimura*, Yoshihiro Sasaki, Kazunari Akiyoshi*
Thermoresponsive Carbohydrate-b-Polypeptoid Polymer Vesicles with Selective Solute Permeability and Permeable Factors for Solutes
Biomacromolecules, 2021, 22, 7, 3099, https://doi.org/10.1021/acs.biomac.1c00530 
- Tomoki Nishimura*, Yoshihiro Sasaki, Kazunari Akiyoshi
Thermoresponsive Glycopolymer Vesicles: In situ Observation of Morphological Changes and Triggered Cargo Release
Polymer Journal, 2021, 53, 1251, https://doi.org/10.1038/s41428-021-00488-w 
- Riku Kawasaki, Yoshihiro Sasaki*, Tomoki Nishimura, Kiyofumi Katagiri, Kei‐ichi Morita, Yurina Sekine, Shin-ichi Sawada, Sada-atsu Mukai, Kazunari Akiyoshi*
Magnetically Navigated Protein Transduction In Vivo using Iron Oxide-Nanogel Chaperone Hybrid
Advanced Healthcare Materials, 2021, 10(9), 2001988, https://doi.org/10.1002/adhm.202001988 
2020
- Tomoki Nishimura*, Yusuke Nakamura, Naoya Kinoshita, Katsuhiro Yamamoto, Yoshihiro Sasaki, Kazunari Akiyoshi*
Biocatalytic Hybrid Films Self-Assembled from Carbohydrate Block Copolymers and Polysaccharides for Enzyme Prodrug Therapy
ACS Applied Bio Materials, 2020, 3(12), 8865, https://doi.org/10.1021/acsabm.0c01174 
- Tomoki Nishimura*, Liliana de Campo, Hiroki Iwase, Kazunari Akiyoshi*
Determining the Hydration in the Hydrophobic Layer of Permeable Polymer Vesicles by Neutron Scattering
Macromolecules, 2020, 53, 17, 7546, https://doi.org/10.1021/acs.macromol.0c01261 
- Tomoki Nishimura*, Shen Shishi, Yoshihiro Sasaki, Kazunari Akiyoshi*
Thermoresponsive Polysaccharide Graft Polymer Vesicles with Tunable Size and Structural Memory
Journal of the American Chemical Society, 2020, 142, 27, 11784,https://doi.org/10.1021/jacs.0c02290 
- Tomoki Nishimura, Kazunari Akiyoshi*
Artificial Molecular Chaperone Systems for Proteins, Nucleic Acids, and Synthetic Molecules
Bioconjugate Chemistry, 2020, 31, 5, 1259, https://doi.org/10.1021/acs.bioconjchem.0c00133 
- Tomoki Nishimura*, Shin Hirose, Yoshihiro Sasaki, Kazunari Akiyoshi*
Substrate-sorting nanoreactors based on permeable peptide polymer vesicles and hybrid liposomes with synthetic macromolecular channels
Journal of the American Chemical Society, 2020, 142, 1, 154, https://doi.org/10.1021/jacs.9b08598 
2019
- Tomoki Nishimura*, Naoki Sumi, Sada-atsu Mukai, Yoshihiro Sasaki, Kazunari Akiyoshi*
Supramacromolecular injectable hydrogels by crystallization-driven self-assembly of carbohydrate-conjugated poly(2-isopropyloxazoline) s for biomedical applications
Journal of Materials Chemistry B, 2019, 7, 14, 6362, https://doi.org/10.1039/C9TB00918C 
- Shigeo Takeda, Tomoki Nishimura, Kaori Umezaki, Akiko Kubo, Michiyo Yanase, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi*
Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery
Biomaterials, Science, 2019, 7, 4, 1617, https://doi.org/10.1039/C8BM01627E 
- Tomoki Nishimura, Naoki Sumi, Yuta Koda, Yoshihiro Sasaki, Kazunari Akiyoshi*
Intrinsically permeable polymer vesicles based on carbohydrate-conjugated poly(2-oxazoline) s synthesized using a carbohydrate-based initiator system
Polymer Chemistry, 2019, 10, 6, 691, https://doi.org/10.1039/C8PY01502C 
2018
- Tomoki Nishimura, Wei‐Lun Toh, Kazunari Akiyoshi*
Synthesis and Characterization of Shell‐Cross‐Linked Glycopolymer Bilayer Vesicles
Macromolecular Rapid Communications, 2018, 39, 23, 1800384, https://doi.org/10.1002/marc.201800384 
- Tomoki Nishimura, Kazunari Akiyoshi*
Biotransporting biocatalytic reactors toward therapeutic nanofactories
Advanced Science, 2018, 5, 11, 1800801, https://doi.org/10.1002/advs.201800801 
2017
- Tomoki Nishimura, Akina Yamada, Kaori Umezaki, Shin-ichi Sawada, Sada-atsu Mukai, Yoshihiro Sasaki, Kazunari Akiyoshi*
Self-assembled polypeptide nanogels with enzymatically transformable surface as a small interfering RNA delivery platform
Biomacromolecules, 2017, 18, 12, 3913, https://doi.org/10.1021/acs.biomac.7b00937 
- Tomoki Nishimura, Yoshihiro Sasaki, Kazunari Akiyoshi*
Biotransporting Self‐Assembled Nanofactories Using Polymer Vesicles with Molecular Permeability for Enzyme Prodrug Cancer Therapy
Advanced Materials, 2017, 29, 36, 1702406, https://doi.org/10.1002/adma.201702406 
- Tomoki Nishimura, Kazunari Akiyoshi*
Amylose engineering: phosphorylase‐catalyzed polymerization of functional saccharide primers for glycobiomaterials
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2017, 9, 2, e1423, https://doi.org/10.1002/wnan.1423 
Before 2016
- Yoshiro Tahara, Mizuki Sakiyama, Shigeo Takeda, Tomoki Nishimura, Sada-atsu Mukai, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi
Self-assembled nanogels of cholesterol-bearing hydroxypropyl cellulose: a thermoresponsive building block for nanogel tectonic materials
Langmuir, 2016, 32, 47, 12283, https://doi.org/10.1021/acs.langmuir.6b02406
- Tomoki Nishimura, Masahiro Takara, Sada-atsu Mukai, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi
A light sensitive self-assembled nanogel as a tecton for protein patterning materials
Chemical Communications, 2016, 52, 6, 1222, https://doi.org/10.1039/C5CC08416D
- Tomoki Nishimura, Kaori Umezaki, Sada-atsu Mukai, Shin-ichi Sawada, Kazunari Akiyoshi
Amylose-based cationic star polymers for siRNA delivery
BioMed Research International, 2015, 962941, https://doi.org/10.1155/2015/962941
- Minnie Chan, Jacques Lux, Tomoki Nishimura, Kazunari Akiyoshi, Adah Almutairi
Long-lasting and efficient tumor imaging using a high relaxivity polysaccharide nanogel magnetic resonance imaging contrast agent
Biomacromolecules, 2015, 16, 9, 2964, https://doi.org/10.1021/acs.biomac.5b00867
- Tomoki Nishimura, Sada-atsu Mukai, Shin-ichi Sawada, Kazunari Akiyoshi
Glyco star polymers as helical multivalent host and biofunctional nano-platform
ACS Macro Letters, 2015, 4, 4, 367, https://doi.org/10.1021/acsmacrolett.5b00049
- Katherine Lawrence, Tomoki Nishimura, Peter Haffenden, John M Mitchels, Kazuo Sakurai, John S Fossey, Steven D Bull, Tony D James
Frank Marken, Pyrene-anchored boronic acid receptors on carbon nanoparticle supports: fluxionality and pore effects
New Journal of Chemistry, 2013, 37, 7, 1883, https://doi.org/10.1039/C3NJ00017F
- Tomoki Nishimura, Su-Ying Xu, Yun-Bao Jiang, John S Fossey, Kazuo Sakurai, Steven D Bull, Tony D James
A simple visual sensor with the potential for determining the concentration of fluoride in water at environmentally significant levels
Chemical Communications, 2013, 46, 5, 478, https://doi.org/10.1039/C2CC36107H
- Tomoki Nishimura, Yusuke Sanada, Takuma Matsuo, Tadashi Okobira, Efstratios Mylonas, Naoto Yagi, Kazuo Sakurai
A bimolecular micelle constructed from amphiphilic pillar [5] arene molecules
Chemical Commucations, 2013, 46, 23, 3052, https://doi.org/10.1039/C3CC41186A
- Shota Fujii, Tomoki Nishimura, Kazuo Sakurai
Thermodynamics of lipoplex formation: relationship between the lipid alkyl tail length and thermodynamic functions
Chemistry Letters, 2012, 41, 5, 501, https://doi.org/10.1246/cl.2012.501
- Shota Fujii, Yusuke Sanada, Tomoki Nishimura, Isamu Akiba, Kazuo Sakurai, Naoto Yagi
Efstratios Mylonas, A stimulus-responsive shape-persistent micelle bearing a calix [4] arene building block: reversible pH-dependent transition between spherical and cylindrical forms
Langmuir, 2012, 28, 6, 3092, https://doi.org/10.1021/la2037668
- Takuma Matsuo, Shota Fujii, Yumi Kamikawa, Tomoki Nishimura, Yusuke Sanada, Shinichi Mochizuki, Kazuo Sakurai
Quaternary-ammonium-bearing Aromatic Surfactants: Effect of the Alkyl Chain Positions on Their Micelle and DNA-complex Structures
Chemistry Letters, 2011, 40, 12, 1340, https://doi.org/10.1246/cl.2011.1340
- Tomoki Nishimura, Takuma Matsuo, Kazuo Sakurai
Metal-ion induced transition from multi-to single-bilayer tubes in histidine bearing lipids and formation of monodisperse Au nanoparticles
Physical Chemistry Chemical Physics, 2011, 13, 35, 15899, https://doi.org/10.1039/C1CP21065C
- Tomoki Nishimura, Takeshi Cho, Andrew M Kelley, Magdalena E Powell, John S Fossey, Steven D Bull, Tony D James, Hiroyasu Masunaga, Isamu Akiba, Kazuo Sakurai
Synthesis of a highly hydrophobic cationic lipid and structural and thermodynamic studies for interaction with DNA
Bulletin of the Chemical Society of Japan, 2010, 83, 9, 1010, https://doi.org/10.1246/bcsj.20100072
- Tomoki Nishimura, Hiroyasu Masunaga, Hiroki Ogawa, Isamu Akiba, Kazuo Sakurai
Cation-specific Transition from Vesicle to Lamella for an Aromatic Diamine Lipid in Aqueous Solutions
Chemistry Letters, 2010, 39, 7, 686, https://doi.org/10.1246/cl.2010.686
- Tomoki Nishimura, Tadashi Okobira, Andrew M Kelly, Naohiko Shimada, Yoichi Takeda, Kazuo Sakurai
DNA binding of tilorone: 1H NMR and calorimetric studies of the intercalation
Biochemistry, 2007, 46, 27, 8156, https://doi.org/10.1021/bi602402m
- Tomoki Nishimura, Yoichi Takeda, Naohiko Shimada, Kazuo Sakurai
DNA conformational switching by use of an intercalator and its receptor
Chemistry Letters, 2007, 36, 3, 388, https://doi.org/10.1246/cl.2007.388
Books
- 西村 智貴、多糖の折り畳みを利用した分子組織化、 高分子、トピックス、 73巻、 4月号、 2024年
- 西村 智貴、高分子材料合成におけるクリックケミストリー、Drug Delivery System、DDSの「ちょっとした」技術・知識 第22回、 vol.38、 No.5、 pp. 450、 2023年
- 坂本 悠輔、西村 智貴、超分子グライコヒドロゲルの抗がん剤プロドラッグ変換場としての機能、 低分子ゲル・超分子ゲルの設計開発と応用、第4章ゲルの活用・応用、 pp. 204、 NTS出版、 ISBN:978-4-7813-1749-6、2023年
- 西村 智貴、くすりを疾患部位で作る医用反応場の創製、 Drug Delivery System、若手研究者のひろば、vol.38、 No.1、 pp. 82、 2023年
- 西村 智貴、分子を通す人工二分子膜ベシクルの創製、 化学と工業、飛翔する若手研究者、vol.74-11、 pp. 864-865、 2021年
- 西村 智貴、強みを築く、 高分子、グローイングポリマー、 70巻、 11月号、 2021年
- 西村 智貴、分子透過能を有する高分子ベシクルの設計・機能・材料応用、 膜、 46、 4、 192、 2021年
- 西村 智貴、秋吉 一成、関根 由莉奈、中性子・X線小角散乱法によるDDSナノキャリアの精密構造解析、 波紋、 30、 2、 102、 2020年
- 西村 智貴、秋吉 一成,糖鎖高分子ベシクルの設計とDDSナノファクトリーとしての機能、 Drug delivery system、 34-3号、 pp. 154-162、 2019年
- 西村 智貴、秋吉 一成、「生命機能に迫る分子化学：生命分子を真似る、飾る、超える(CSJ Current Review)」、 分子シャペロン機能を有する人工分子システム、 第2部 研究最前線 6章、 ISBN 9784759813906
- 西村 智貴、秋吉 一成「糖鎖の新機能開発・応用ハンドブック 創薬・医療から食品開発まで」、 第４章 第５節 ブロックポリマーの酵素合成、 NTS出版、 ISBN:978-4-86043-409-0
- 西村 智貴、秋吉 一成「応用が拡がるDDS ~人体環境から農業・家電まで~」 第１章、 第４節 DDSキャリアの最前線 ナノゲル、NTS出版、 ISBN:978-4-86469-070-6
